Results - electrical polarity of the most important channels

PW2e

Fig. 23 CYP2C: output channels PW2e have the only one same residue - LYS 118.

Fig. 24 CYP3A: residues in both structures are identical. Near the output is a negatively charged region. Towards the heme is a positive region.



Fig. 25



Fig. 26

On the output of B / C loop is always present at least one negatively charged residue.