Results - electrical polarity of the most important channels

PW2c

Fig. 18 For CYP2C8 predominates positively charged landscape, in contrast to CYP2C9 doubled incidence of glutamines.

Fig. 19 CYP3A: F / G, the landscape is different hydrophilic cysteine and positive ARG  243.
Helix G and B / C loop consists of positively charged residues of 2C and 3A subfamilies.

Fig. 20



Fig. 21

The structures of figures 20, 21: amino acids differ in characteristics, the orientation is slightly similar.